#Pcad 2006 reports registration

Non-primary publications often analyzed and reported multiple different outcomes (16% reported >20 outcomes) and in 10% ( n = 7) it was unclear how many outcomes had actually been assessed in 42% ( n = 29) it was unclear whether the analyses reported were pre-specified or exploratory.

#Pcad 2006 reports registration

Less than half reported details of trial registration ( n = 30 43%) or the trial protocol ( n = 27 39%) and in 41% ( n = 28) it was unclear from reading the abstract that the report was not the primary publication for the trial. Most reported subgroup analyses ( n = 27 39%), analyzing a specific subgroup of patients from the randomized trial, or reported on secondary outcomes ( n = 29 42%) 19% ( n = 13) reported extended follow-up. The majority ( n = 56 81%) of non-primary publications were large, multicenter trials, published in specialty journals. We also compared consistency of information in non-primary publications with that reported in the primary publication. We carried out a cross-sectional review of the characteristics and type of information reported in non-primary reports ( n = 69) of randomized trials (indexed in PubMed core clinical journals in 2009) and whether they report pre-specified or exploratory analyses. Other aspects of a randomized trialвЂ™s findings (that is, non-primary results) are often reported in subsequent publications. For a randomized trial, the primary publication is usually the one which reports the results of the primary outcome and provides consolidated data from all study centers.